PXD078554

PXD078554 is an original dataset announced via ProteomeXchange.

Title	Qualitative assessment of nasopharyngeal aspirates as an alternative to tracheal aspirates in extremely preterm infants
Description	The search for novel biomarkers for respiratory diseases, especially those associated with extreme premature birth, has been a challenge over the past several decades. In this study, we performed a qualitative comparison of proteomic profiles derived from a novel noninvasive sampling methodology, nasopharyngeal aspiration, and an established invasive methodology, tracheal aspiration, in preterm neonates, to determine whether nasopharyngeal aspirates (NPAs) are suitable for respiratory biomarker research. Paired NPA and tracheal aspirate (TA) samples (N=5) were collected from 1-week-old neonates and analyzed via high-throughput proteomics. The shared and specific sample proteins were studied. Shared and sample-specific proteins were analyzed using state-of-the-art enrichment analyses to evaluate lung tissue specificity and proteomic similarity.
HostingRepository	PRIDE
AnnounceDate	2026-06-11
AnnouncementXML	Submission_2026-06-11_01:14:50.001.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD078554
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Fernando Garrido-Muñoz
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-05-19 07:31:55	ID requested
1	2026-06-11 01:12:37	announced
⏵ 2	2026-06-11 01:14:50	announced	2026-06-11: Updated project metadata.

10.6019/PXD078554;

10.3389/fped.2026.1804309;

submitter keyword: Neonate,Lung Diseases, Bronchopulmonary dysplasia, Proteomics, Data Collection, Computational Biology

Almudena Alonso-Ojembarrena
contact affiliation	Neonatal Intensive Care Unit. Puerta del Mar University Hospital, Cádiz (Spain)
contact email	almudena.alonso.sspa@juntadeandalucia.es
lab head
Fernando Garrido-Muñoz
contact affiliation	Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain
contact email	fgarrido-ibis@us.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD078554

PRIDE project URI

• PRIDE
  1. PXD078554
     1. Label: PRIDE project
     2. Name: Qualitative assessment of nasopharyngeal aspirates as an alternative to tracheal aspirates in extremely preterm infants