⮝ Full datasets listing
PXD078538
PXD078538 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Early Proteomic and Metabolomic Signatures in Diabetes Associated with Progression to Diabetic Retinopathy Over 1–2 Years |
| Description | In this study, we leveraged 15 paired plasma samples collected from the same individuals who exhibited rapid progression from DM to DR within 1-2 years and conducted integrated proteomic and metabolomic analyses to investigate molecular changes associated with disease progression. Key proteins were validated by ELISA in an independent cohort of 22 DM and 22 NPDR patients and their predictive performance was assessed using receiver operating characteristic (ROC) curve analysis. The results revealed significant alterations at both the protein and metabolite levels during the progression from DM to DR. Among the validated proteins, three ((ANXA1, GPX1, and GSTM1) were previously reported in DR, while five (ALDH18A1, GALT, PRG2, UBA1, and GCA) represent newly identified candidates. ROC analysis demonstrated strong discriminative performance for these proteins, with area under the curve (AUC) values ranging from 0.853 to 0.945. These findings provide insight into the molecular mechanisms underlying early DR progre |
| HostingRepository | iProX |
| AnnounceDate | 2026-05-19 |
| AnnouncementXML | Submission_2026-05-19_00:02:46.730.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jing Zhao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF; LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-19 00:02:26 | ID requested | |
| ⏵ 1 | 2026-05-19 00:02:47 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Diabetic Retinopathy |
Contact List
| Jing Zhao | |
|---|---|
| contact affiliation | Xi'an People's Hospital (Xi'an Fourth Hospital) |
| contact email | 18710157200@163.com |
| lab head | |
| Jing Zhao | |
| contact affiliation | Xi'an People's Hospital (Xi'an Fourth Hospital) |
| contact email | 18710157200@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
