PXD078485 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mass Spectrometry Profiling of Lysosomal IP under Normoxia and Hypoxia-Reoxygenation |
| Description | This project employed TMEM192-3×Flag-mediated lysosome immunoprecipitation (Lyso-IP) followed by mass spectrometry to investigate lysosomal proteomes under normoxia and hypoxia/reoxygenation (H/R) stress. Our study focuses on the mechanisms of lysosomal renewal, revealing that damaged lysosomes undergo budding-type fission (B-fission) to produce functional daughter lysosomes. The dataset provides a comprehensive resource for exploring stress-responsive lysosomal proteins and organelle quality control pathways. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-03 |
| AnnouncementXML | Submission_2026-06-02_22:50:09.529.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhuofan Li |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Ascend |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-05-18 03:45:48 | ID requested | |
| ⏵ 1 | 2026-06-02 22:50:10 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Human,B-fission |
Contact List
| Zhiyin Song |
|---|
| contact affiliation | Department of Pathology, School of Basic Medicinel, Tongji Medical Collegells, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China |
| contact email | songzy@hust.edu.cn |
| lab head | |
| Zhuofan Li |
|---|
| contact affiliation | Tongji Medical College of HUST |
| contact email | lzf15404@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD078485 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD078485
- Label: PRIDE project
- Name: Mass Spectrometry Profiling of Lysosomal IP under Normoxia and Hypoxia-Reoxygenation
