PXD078474

PXD078474 is an original dataset announced via ProteomeXchange.

Title	KAT8-mediated PCBP1 acetylation drives neutrophil recruitment in papain-induced airway inflammation
Description	Emerging evidence implicates KAT8 as a critical modulator of inflammatory responses in lung diseases. Bosch et al. reported that MG149, a KAT8 inhibitor, reduces pro-inflammatory gene expression in lipopolysaccharide (LPS)-stimulated murine lung slices. Additionally, Liu et al. demonstrated that KAT8 promotes the cleavage and release of IL-33 through direct acetylation in airway epithelial cells in asthma models. However, KAT8 regulatory mechanism remains unexplored. To elucidate the molecular mechanism by which KAT8 modulates chemokine expression, we performed immunoprecipitation followed by mass spectrometry (IP-MS) to identify KAT8-interacting proteins. KEGG pathway enrichment analysis of the top 300 proteins with the highest coverage revealed significant enrichment in RNA binding and mRNA processing pathways, identifying these proteins as potential KAT8-interacting partners.
HostingRepository	iProX
AnnounceDate	2026-05-18
AnnouncementXML	Submission_2026-05-18_02:06:01.324.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ruina Huang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2026-05-18 02:05:41	ID requested
⏵ 1	2026-05-18 02:06:01	announced

Dataset with its publication pending

submitter keyword: KAT8, IP-MS, protein-protein interaction, RNA binding, mRNA processing, inflammatory regulation, asthma

Ruina Huang
contact affiliation	The First Dongguan Affiliated Hospital
contact email	wolidedd@163.com
lab head
Ruina Huang
contact affiliation	The First Dongguan Affiliated Hospital
contact email	wolidedd@163.com
dataset submitter

iProX dataset URI