PXD078462

PXD078462 is an original dataset announced via ProteomeXchange.

Title	ILC2-intrinsic IL-33 promotes ILC2 activation and exacerbates allergic lung 1 inflammation
Description	Mass spectrometry-based proteomics serves as an invaluable tool for pinpointing critical biomarkers and elucidating cellular functions and regulatory pathways. However, the proteomic changes in ILC2s during activation remain unexplored. To characterize the dynamic proteomic profiles of lung-resident ILC2s under physiological and inflammatory conditions, we performed high-resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS) to systematically compare the molecular signatures of FACS-purified pulmonary ILC2 populations (Live CD45+CD90.2+Lineage- ST2+) isolated from two experimental groups: 1) steady-state control mice and 2) papain-challenged mice exhibiting acute airway inflammation (Fig. 1a and Supplementary Fig. 1a). Papain-induced lung inflammation was chosen because papain is a classical protease allergen triggering the release of pro-inflammatory factors including IL-33 to develop ILC2-derived lung inflammation.
HostingRepository	iProX
AnnounceDate	2026-05-16
AnnouncementXML	Submission_2026-05-18_00:23:47.309.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liming Sun
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-05-18 00:23:13	ID requested
⏵ 1	2026-05-18 00:23:47	announced

Dataset with its publication pending

submitter keyword: ILC2 activation, DDA, Timstof Pro

Rong Zeng
contact affiliation	University of Shanghaitech
contact email	zengrong@shanghaitech.edu.cn
lab head
Liming Sun
contact affiliation	University of Chinese Academy of Sciences
contact email	sunlm@ucas.ac.cn
dataset submitter

iProX dataset URI