PXD078448

PXD078448 is an original dataset announced via ProteomeXchange.

Title	Role and Mechanism of SERPINA1/PLG/TGFB1-Induced Adipose Fibroblast Activation in Dorsal Cervical Adipose Accumulation
Description	This study presents an integrated metabolomics and proteomics analysis of human adipose tissue from two groups (A and B, n=7 each). Untargeted metabolomics (LC‑MS/MS) identified 2,305 metabolites, with 145 significantly different between groups (73 up, 72 down in Group A). The metabolomics data are available under MTBLS14456 in MetaboLights. Complementary proteomics analysis on the same samples quantified protein expression differences using label‑free LC‑MS/MS. The combined multi‑omics dataset reveals molecular signatures differentiating the two groups and provides a valuable resource for understanding adipose tissue metabolism
HostingRepository	iProX
AnnounceDate	2026-05-15
AnnouncementXML	Submission_2026-07-01_01:08:07.216.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Runze Yang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	CAMERA

Revision	Datetime	Status	ChangeLog Entry
0	2026-05-17 23:56:20	ID requested
⏵ 1	2026-07-01 01:08:07	announced

Dataset with its publication pending

submitter keyword: Proteomics, Untargeted metabolomics, Human adipose tissue, Liquid chromatography-tandem mass spectrometry, Differential metabolites, Biomarker, KEGG pathway enrichment

Yujing Zhang
contact affiliation	First hospital of China Medical University
contact email	yjzhang@cmu.edu.cn
lab head
Runze Yang
contact affiliation	First hospital of China Medical University
contact email	yrz000108@163.com
dataset submitter

iProX dataset URI