PXD078403

PXD078403 is an original dataset announced via ProteomeXchange.

Title	A bacterial pathway for homotaurine catabolism via sulfopropanoate – homotaurine vs glucose
Description	Homotaurine (3-aminopropanesulfonic acid) and sulfopropanoate (3-oxopropanesulfonic acid), its oxidative deamination product, are C3-organosulfonates that occur in marine algal metabolism, the human diet and microbial sulfur cycling. Here we report the identification and characterization of a complete bacterial pathway for catabolism of homotaurine via sulfopropanoate. The pathway involves three phases: import of homotaurine and conversion to sulfopropanoate through the known nitrogen assimilation pathway, transformation of sulfopropanoate to sulfolactate through a new pathway that bears close resemblance to steps in the citric acid cycle, and finally, biomineralization using a known pathway for sulfolactate breakdown. The core sulfopropanoate to sulfolactate module is widespread and emphasizes the important of this transformation as a key module in C3-(amino)organosulfonate breakdown.
HostingRepository	PRIDE
AnnounceDate	2026-09-09
AnnouncementXML	Submission_2026-09-08_17:51:55.049.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nichollas Scott
SpeciesList	scientific name: Caballeronia jiangsuensis; NCBI TaxID: NEWT:1458357;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2026-05-15 04:52:38	ID requested
⏵ 1	2026-09-08 17:51:55	announced

Dataset with its publication pending

submitter keyword: sulfopropanoate,homotaurine

Spencer J. Williams
contact affiliation	School of Chemistry, University of Melbourne, Parkville, Victoria 3010, Australia Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
contact email	sjwill@unimelb.edu.au
lab head
Nichollas Scott
contact affiliation	University of Melbourne
contact email	nichollas.scott@unimelb.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD078403

PRIDE project URI

• PRIDE
  1. PXD078403
     1. Label: PRIDE project
     2. Name: A bacterial pathway for homotaurine catabolism via sulfopropanoate – homotaurine vs glucose