⮝ Full datasets listing
PXD078256
PXD078256 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | NLRP3 interacting molecules in tumor and myeloid cells |
| Description | Hypothesis and Rationale for Mass Spectrometry Analysis to Identify the NLRP3 binding partners in tumor cells We found that tumor-intrinsic NLRP3 activation promotes tumor growth and causes resistance to immunotherapy by recruiting PMN myeloid suppressor cells and inhibiting CD8 T cell activity. Targeting NLRP3 with NLRP3 inhibitors inhibits NLRP3 activity in myeloid cells as well. Studies have shown that myeloid NLRP3 activity either inhibits or promotes tumor growth by regulating immunity against tumors. Therefore, we proposed identifying tumor-intrinsic binding partners that are excluded from myeloid cells during NLRP3 activity. Identifying tumor-specific NLRP3 regulators would help target tumor-specific NLRP3 activity. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-05-12 |
| AnnouncementXML | Submission_2026-05-12_20:07:52.360.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Balamayooran Theivanthiran |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | unknown modification |
| Instrument | instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-12 19:56:54 | ID requested | |
| ⏵ 1 | 2026-05-12 20:07:52 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: NLRP3 binding molecules, DatasetType:Proteomics |
Contact List
| Brent A Hanks | |
|---|---|
| contact affiliation | UNC at Chapel Hill |
| contact email | bhanks@email.unc.edu |
| lab head | |
| Balamayooran Theivanthiran | |
| contact email | tbala@email.unc.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v13/MSV000101820/ |
