⮝ Full datasets listing
PXD078247
PXD078247 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Serum proteome profiling of patients with non-small cell lung cancer treated with immune checkpoint blockade monotherapy |
| Description | Shotgun proteomic profiling of serum from patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint blockade (ICB) monotherapy. Top-14 abundant proteins were depleted (Pierce High-Select, Thermo Fisher Scientific), and tryptic digests were spiked with the Pierce Peptide Retention Time Calibration Mixture as an internal standard. Peptides were analyzed by LC-MS/MS on an EASY-nLC 1200 coupled to an Orbitrap Eclipse Tribrid mass spectrometer with a FAIMS Pro interface (compensation voltages −40, −60, −80 V), using data-dependent acquisition with Orbitrap MS1 and ion-trap-detected HCD MS2. Raw files were searched in Proteome Discoverer 2.4 (SEQUEST HT with Percolator validation) against UniProt Swiss-Prot human (release 2017-10-25), and label-free protein abundances (Minora Feature Detector) were normalized to internal standard peptides. See the associated publication for full experimental details and clinical information. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-06-10 |
| AnnouncementXML | Submission_2026-06-09_08:00:04.824.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuki Miyai |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide; Met-loss; Met-loss+Acetyl |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-11 22:54:08 | ID requested | |
| ⏵ 1 | 2026-06-09 08:00:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: human |
| serum |
| label-free quantification |
| immune checkpoint blockade |
| non-small cell lung cancer |
Contact List
| Tetsunari Hase | |
|---|---|
| lab head | |
| Yuki Miyai | |
| contact affiliation | Nagoya University Hospital |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST004613/ |
