⮝ Full datasets listing
PXD078216
PXD078216 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Liver proteomic profiling of mice with hepatic Ier2 overexpression following acetaminophen (APAP) administration |
| Description | This study aims to investigate the role of IER2 in acetaminophen (APAP)- induced liver injury. Male C57BL/6J mice were randomized to receive a single tail vein injection of either AAV8-GFP or AAV8-Ier2. Mice were fasted overnight for 14 hours followed by intraperitoneal administration of APAP (500 mg/kg). Animals were sacrificed 8 hours post-APAP challenge, and liver tissues were collected for proteomic profiling. This study aims to characterize the proteomic changes associated with IER2 overexpression during APAP hepatotoxicity, thereby establishing a foundation for subsequent mechanistic investigations. |
| HostingRepository | iProX |
| AnnounceDate | 2026-05-10 |
| AnnouncementXML | Submission_2026-07-01_00:58:34.943.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Peng Jiang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-10 20:19:56 | ID requested | |
| ⏵ 1 | 2026-07-01 00:58:35 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: acetaminophen, IER2, liver injury, proteomics |
Contact List
| Zhihua Wang | |
|---|---|
| contact affiliation | University of Science and Technology of China |
| contact email | wangzh@ustc.edu.cn |
| lab head | |
| Peng Jiang | |
| contact affiliation | University of Science and Technology of China |
| contact email | jiangp@ustc.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
