⮝ Full datasets listing
PXD078174
PXD078174 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrative multi-omics landscape reveals B. ovis negatively regulates RAW264.7 macrophages autophagy via lncRNA 225639-Ctsb axis and promotes B. ovis intracellular survival |
| Description | This study investigates the mechanism by which Brucella ovis evades host clearance. Using integrative multi-omics analysis (transcriptome, proteome, and lncRNAome), we identified a novel regulatory axis where lncRNA 225639 negatively regulates autophagy in RAW264.7 macrophages by modulating Cathepsin B (Ctsb) expression, thereby promoting intracellular bacterial survival. |
| HostingRepository | iProX |
| AnnounceDate | 2026-05-19 |
| AnnouncementXML | Submission_2026-05-19_02:19:16.286.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jiya Li |
| SpeciesList | scientific name: Brucella ovis; NCBI TaxID: 236; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-08 18:11:15 | ID requested | |
| ⏵ 1 | 2026-05-19 02:19:16 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Brucella ovis, lncRNA225639-Ctsb axis, RAW264.7 macrophages, Autophagy, Intracellular survival |
Contact List
| Hanwei Jiao | |
|---|---|
| contact affiliation | Southwest University |
| contact email | jiaohanwei@swu.edu.cn |
| lab head | |
| Jiya Li | |
| contact affiliation | Southwest University |
| contact email | 2373543338@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
