PXD078146 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | LC-MS/MS analysis of proteomic changes in the spinal cord during experimental autoimmune encephalomyelitis |
| Description | Experimental autoimmune encephalomyelitis (EAE) is a key model of autoimmune neuroinflammation, yet an integrated characterization of transcriptional dysregulation in the central nervous system has been limited. In this study, we performed proteomic profiling of dysregulated gene expression in the spinal cord of female and male C57BL/6JRccHsd mice induced with EAE during the acute disease phase using TMT LC-MS/MS. The associated transcriptomics dataset (RNA-sequencing analysis of transcriptomic changes in the spinal cord during experimental autoimmune encephalomyelitis) can be found on GEO. We identified extensive upregulation of innate and adaptive immune response signatures alongside downregulation of neuronal, synaptic, and mitochondrial pathways at the transcript level. Comparative analyses revealed broad pathway‑level changes associated with neuroinflammation, while highlighting limitations of transcriptomics alone in capturing alterations related to synaptic and metabolic integrity. This dataset provides a resource for investigating molecular remodeling of the inflamed central nervous system during autoimmune neuroinflammation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-13 |
| AnnouncementXML | Submission_2026-07-12_16:09:35.721.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD078146 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Elena Prepoudis |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monohydroxylated residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-05-07 20:48:03 | ID requested | |
| ⏵ 1 | 2026-07-12 16:09:36 | announced | |
Publication List
| 10.1186/s40478-026-02365-0; |
| Prepoudis E, Pfister S, Hofmann A, Altorfer M, Catalano M, Sindelar M, Ramseier P, Lafossas F, Tisserand S, Junt T, Schubart A, Locatelli G, Solovyeva E, Integrated proteogenomic profiling reveals coordinated differential expression signatures during neuroinflammation. Acta Neuropathol Commun, ():(2026) [pubmed] |
| 10.6019/PXD078146; |
Keyword List
| submitter keyword: neuroinflammation, proteomics, proteogenomics, LS-MS/MS,Experimental autoimmune encephalomyelitis, mouse, spinal cord |
Contact List
| Elizaveta Solovyeva |
|---|
| contact affiliation | Novartis AG Basel |
| contact email | elizaveta.solovyeva@novartis.com |
| lab head | |
| Elena Prepoudis |
|---|
| contact affiliation | University of Basel, Novartis AG Basel |
| contact email | elena.prepoudis@hotmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD078146 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD078146
- Label: PRIDE project
- Name: LC-MS/MS analysis of proteomic changes in the spinal cord during experimental autoimmune encephalomyelitis
