PXD078145

PXD078145 is an original dataset announced via ProteomeXchange.

Title	Metabolic enzymes of human SGBS adipocytes interact with halogenated bisphenol A alternatives – Full Proteome
Description	This dataset contains quantitative proteomics data of differentiated human SGBS adipocytes treated with bisphenols (10 nM and 10 µM) and the AKR1C1 inhibitor 3-bromo-5-phenylsalicylic acid. Cells were exposed for 24 h, 4 days, and 8 days, alongside rosiglitazone, GW9662, and DMSO controls, with four biological replicates per condition. Proteins were extracted, digested using SP3-based sample preparation, and analyzed by LC-MS/MS in DIA mode on an Orbitrap Astral mass spectrometer. Data were processed using DIA-NN and statistically evaluated to identify differentially abundant proteins.
HostingRepository	PRIDE
AnnounceDate	2026-08-13
AnnouncementXML	Submission_2026-08-13_04:08:58.913.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jasmin Kleißen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-05-07 19:27:03	ID requested
⏵ 1	2026-08-13 04:08:59	announced

10.1016/J.JHAZMAT.2026.143238;

ProteomeXchange project tag: Toxicoproteomics (B/D-HPP), Human Proteome Project

submitter keyword: thermal proteome profiling,BPA, halogenated BPA alternatives, TCA cycle, steroid metabolism., adipocytes, metabolic disruption

Kristin Schubert
contact affiliation	Previous: Department of Molecular Toxicology, Helmholtz-Centre for Environmental Research GmbH (UFZ), Leipzig, Germany. Current: Cell Biology, Faculty of Environment and Natural Science, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany
contact email	kristin.schubert@b-tu.de
lab head
Jasmin Kleißen
contact affiliation	UFZ Leipzig
contact email	jasmin.kleissen@ufz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD078145

PRIDE project URI

• PRIDE
  1. PXD078145
     1. Label: PRIDE project
     2. Name: Metabolic enzymes of human SGBS adipocytes interact with halogenated bisphenol A alternatives – Full Proteome