⮝ Full datasets listing
PXD078009
PXD078009 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proximity-Informed Graph Learning Defines Spatial Protein Communities for Tumor-Associated Proximity Antigen Discovery |
| Description | The spatial organization of membrane proteins is an underexplored dimension of cell-surface biology. Spatial proximity shapes cellular function and therapeutic targetability, yet efforts to identify tumor-associated antigens (TAAs) have largely focused on expression alone. Here, we developed an industrialized surface-protein proximity mapping workflow to interrogate TAAs within their membrane microenvironments. In the process, we generated 248 proximity maps across 12 receptor tyrosine kinases (RTKs) and 28 tumor cell systems. This proximity atlas enabled two advances: first, MetaMap, a correlation-based analytical framework that defines spatial protein communities and infers non-targeted proximal proteins from reproducible proximity signatures; and second, tumor-associated proximity antigens (TAPAs), a conceptual class of co-targets defined by disease-specific spatial proximity to TAAs rather than expression alone. Applying these proximity-derived relationships within a multimodal prioritization framework, we identify and validate an EGFR/CDCP1 TAA/TAPA pair that enhances tumor cell killing across therapeutic modalities. By integrating spatial organization with multimodal data, this work expands the design space for precision-guided therapeutic strategies. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-07-21 |
| AnnouncementXML | Submission_2026-07-21_09:07:03.379.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Noah Dephoure |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | L-methionine sulfoxide; S-carboxamidomethyl-L-cysteine |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-05-05 08:31:05 | ID requested | |
| ⏵ 1 | 2026-07-21 09:07:03 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: DIA, proximity labeling, TMT, microenvironment mapping, DatasetType:Proteomics |
Contact List
| Noah Dephoure | |
|---|---|
| contact affiliation | Indupro, Inc. |
| contact email | noah@induprotx.com |
| lab head | |
| Noah Dephoure | |
| contact affiliation | Indupro |
| contact email | nanderthol@gmail.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v12/MSV000101727/ |
