PXD077765

PXD077765 is an original dataset announced via ProteomeXchange.

Title	Rat infected Lung by Cryptococcus deuterogattii R265
Description	Cryptococcosis caused by Cryptococcus deuterogattii is a life-threatening fungal infection increasingly reported in immunocompetent individuals. In this analysis we perfomed an experimental infection in adults rats to elucidate molecular alterations in this disease. For experimental infection, rats (n = 6 per group) were anesthetized with intraperitoneal ketamine (75 mg/kg) and xylazine (10 mg/kg). They were divided into: (i) control (no inoculation), (ii) infected intranasally with 0.1 mL of 1 × 10⁹ C. deuterogattii R265 cells for analysis at 3 days post-inoculation (dpi), (iii) same inoculation for analysis at 14 dpi, (ii) infected intranasally with 0.1 mL of 1 × 10⁹ C. deuterogattii R265 cells for analysis at 3 days post-inoculation (dpi), and (iii) same inoculation for analysis at 14 dpi. At 3 and 14 dpi, rats were re-anesthetized, thoracic cavity opened, and lungs removed. Left lungs for proteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2026-05-13
AnnouncementXML	Submission_2026-05-13_08:50:06.590.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Saciloto
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ XL

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-28 17:28:43	ID requested
⏵ 1	2026-05-13 08:50:07	announced

Dataset with its publication pending

submitter keyword: proteomics, Cryptococcosis,Lung, rattus novergicus, Cryptococcus

Walter Orlando Beys da Silva
contact affiliation	Universidade Federal do Rio Grande do Sul (UFRGS), Laboratório de Microbiologia Molecular e Proteômica (LAMMOP), Faculdade de Farmácia
contact email	walter.beys@ufrgs.br
lab head
Laura Saciloto
contact affiliation	Universidade de Campinas
contact email	sacilotolaura@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD077765

PRIDE project URI

• PRIDE
  1. PXD077765
     1. Label: PRIDE project
     2. Name: Rat infected Lung by Cryptococcus deuterogattii R265