PXD077760

PXD077760 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	TAOK3 controls naïve T cell homeostasis
Description	Genetic deletion or kinase inactivation of TAOK3 resulted in a profound, cell-intrinsic loss of naive CD8⁺ T cells. Despite enhanced sensitivity to TCR ligation and enhanced downstream signalling, proliferating CD8⁺ T cells did not survive in vitro and anti-viral CD8⁺ T cell immunity was compromised in vivo in the absence of TAOK3. To delineate the molecular pathways governed by TAOK3, we performed an unbiased phosphoproteomic analysis of Taok3-deficient cells.
HostingRepository	PRIDE
AnnounceDate	2026-06-02
AnnouncementXML	Submission_2026-06-02_02:10:20.500.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Teresa Mendes Maia
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Exploris 240

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-28 14:51:59	ID requested
⏵ 1	2026-06-02 02:10:22	announced

Publication List

10.3389/FIMMU.2026.1838764;

10.3389/FIMMU.2026.1838764;

Keyword List

submitter keyword: Ste20 kinase, TCR signaling,Naïve T cells, phospho-proteomics

submitter keyword: Ste20 kinase, TCR signaling,Naïve T cells, phospho-proteomics

Contact List

Sahine Lameire
contact affiliation	VIB Inflammation Research Center Ghent University
contact email	sahine.lameire@irc.vib-ugent.be
lab head
Teresa Mendes Maia
contact affiliation	VIB Proteomics Core
contact email	teresa.maia@vib-ugent.be
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD077760
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD077760

PRIDE project URI

Repository Record List

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