⮝ Full datasets listing
PXD077703
PXD077703 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | CRLF1 contributes to acquired resistance to immune checkpoint blockade in mismatch repair-deficient colorectal cancer |
| Description | Immune checkpoint blockade (ICB) has greatly improved survival for mismatch repair-deficient metastatic colorectal cancer (dMMR/dCRC) patients, yet 40%–60% either fail to respond or develop acquired resistance (AR). This study established an anti-PD-1-resistant dCRC model and identified cytokine receptor-like factor 1 (CRLF1) as a key mediator of AR, whose upregulation impairs CD8+ T-cell anti-tumor immunity. |
| HostingRepository | iProX |
| AnnounceDate | 2026-04-27 |
| AnnouncementXML | Submission_2026-04-27_23:38:07.269.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Mengxi Xiu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-04-27 23:37:33 | ID requested | |
| ⏵ 1 | 2026-04-27 23:38:07 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: MC38, mismatch repair-deficient metastatic colorectal cancer, Astral-DIA |
Contact List
| Yong Gao | |
|---|---|
| contact affiliation | Shanghai East Hospital |
| contact email | drgaoyong@tongji.edu.cn |
| lab head | |
| Mengxi Xiu | |
| contact affiliation | Shanghai East Hospital |
| contact email | simon_xiu@tongji.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
