PXD077685

PXD077685 is an original dataset announced via ProteomeXchange.

Title	Physical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice
Description	This project focus on the proteomic changes in AD model mice. AD model mice were established by injecting Aβ₄₂ oligomers into the hippocampus. These mice were then subjected to treadmill training(ADE), 40 Hz audio-visual stimulation(ADVL), or a combination of these interventions(ADEVL). Quantitative proteomics, combined with behavioral tests and molecular analyses, were utilized to evaluate the underlying therapeutic mechanisms of these multimodal interventions in the Aβ₄₂-induced AD model.
HostingRepository	iProX
AnnounceDate	2026-04-27
AnnouncementXML	Submission_2026-08-11_20:31:38.944.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jun Jia
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	L-methionine sulfoxide; S-carboxamidomethyl-L-cysteine
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-27 18:14:46	ID requested
⏵ 1	2026-08-11 20:31:39	announced

Jia J, Xie G, Zheng W, Xu C, Xia Y, Hu Q, Xiang B, Zhou X, Chen A, Chen X, Wang Q, Zhou Y, Xu S, Physical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice via restoring lysosomal membrane integrity. Alzheimers Res Ther, 18(1):(2026) [pubmed]

submitter keyword: Physical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice

Shujun Xu
contact affiliation	Ningbo University
contact email	xushujun@nbu.edu.cn
lab head
Jun Jia
contact affiliation	Ningbo University
contact email	757926632@qq.com
dataset submitter

iProX dataset URI