PXD077631

PXD077631 is an original dataset announced via ProteomeXchange.

Title	Selective organ deposition of nanoparticles directed by metal–organic network coatings_2
Description	Despite significant advances in nanoengineering, developing a universal nanoparticle engineering strategy that enables tailored nanoparticle organ deposition post intravenous administration remains challenging. Here, we report a simple and modular strategy mediated by metal–organic network coatings composed of polyethylene glycol (PEG), proteins, phenolic ligands, and metal ions. The versatile binding affinity of phenolic ligands facilitates the formation of coatings on diverse nanoparticle platforms, including quantum dots, lipid, polymeric, inorganic, and metal–organic nanoparticles. The organ deposition selectivity of these coated nanoparticles is readily directed towards the kidney, lung, heart, and brain by varying the coating composition. Mechanistic studies reveal that the combined effect of PEG, phenolic ligands, and metal ions on the surface properties governs the overall biodistribution of the coated nanoparticles, while the protein component contributes to the coating integrity. This work provides a generalizable approach for developing an organ-targeting nanotechnology, with the potential to advance nanoparticle-mediated treatments and theranostics.
HostingRepository	PRIDE
AnnounceDate	2026-06-26
AnnouncementXML	Submission_2026-06-25_17:49:26.301.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuang Gu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-27 00:47:12	ID requested
⏵ 1	2026-06-25 17:49:26	announced

Dataset with its publication pending

submitter keyword: Nanoparticles

Organ-targeted delivery

Protein corona

Frank Caruso
contact affiliation	Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
contact email	fcaruso@unimelb.edu.au
lab head
Yuang Gu
contact affiliation	Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
contact email	yuang.gu1@unimelb.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD077631

PRIDE project URI

• PRIDE
  1. PXD077631
     1. Label: PRIDE project
     2. Name: Selective organ deposition of nanoparticles directed by metal–organic network coatings_2