⮝ Full datasets listing
PXD077497
PXD077497 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Transcriptome and proteome elucidate the mechanism of spermidine-eIF5Ahyp axis targeted TUFM in regulating autophagy in porcine granulosa cells |
| Description | Autophagy is a conserved pathway essential for granulosa cell homeostasis and follicular development. Spermidine, the sole substrate for eIF5A hypusination (eIF5Ahyp), promotes autophagy and exerts diverse protective effects, including antioxidant and anti-aging activities. This study demonstrates that the spermidine-eIF5Ahyp axis influences autophagy in porcine ovarian granulosa cells by regulating the expression of the downstream protein TUFM. These findings provide mechanistic insights into autophagic regulation in reproductive cells and highlight potential targets for enhancing mammalian fertility. |
| HostingRepository | iProX |
| AnnounceDate | 2026-04-22 |
| AnnouncementXML | Submission_2026-04-22_20:14:24.270.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yun Xuan |
| SpeciesList | scientific name: Sus scrofa; NCBI TaxID: 9823; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-04-22 20:14:00 | ID requested | |
| ⏵ 1 | 2026-04-22 20:14:24 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Autophagy, Granulosa Cells, eIF5A hypusination, Spermidine, TUFM |
Contact List
| Bo Kang | |
|---|---|
| contact affiliation | Sichuan Agricultural University |
| contact email | bokang@sicau.edu.cn |
| lab head | |
| Yun Xuan | |
| contact affiliation | Sichuan Agricultural University |
| contact email | 2370769054@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
