⮝ Full datasets listing
PXD077415
PXD077415 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | An Exploratory Proteomics Study of Autoimmune Premature Ovarian Insufficiency in a Mouse Model |
| Description | Premature ovarian insufficiency (POI) impairs fertility and health in reproductive-age women, with autoimmune factors contributing to 4-30% of cases[1]. To investigate immune dysregulation in POI, we developed two mouse models using pZP3 induction: regular immune (RE-POI) and enhanced immune (EN-POI) cycles. The EN-POI model exhibited stable, irreversible ovarian dysfunction, including disrupted estrous cycles, hormonal changes (elevated FSH, decreased AMH and estradiol), follicular depletion, and infertility. Immune profiling revealed increased CD4+ T cells and decreased regulatory T cells in the spleen, elevated inflammatory cytokines (e.g., interferon-γ, CCL4, CCL5) in serum, and ovarian fibrosis. Proteomics identified 198 differentially expressed proteins enriched in immune and inflammatory pathways. Network analysis highlighted six hub proteins, such as MMP9, ISG15, and IKBKE, with expressions negatively correlating with ovarian reserve markers in human POI. This study establishes a stable autoimmune POI model, elucidates T-cell imbalance with cytokine storm and fibrosis, and identifies key molecules linking immune abnormalities to ovarian failure, offering new insights for POI research. |
| HostingRepository | iProX |
| AnnounceDate | 2026-04-20 |
| AnnouncementXML | Submission_2026-04-20_19:35:55.675.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ying Tian |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-04-20 19:35:27 | ID requested | |
| ⏵ 1 | 2026-04-20 19:35:56 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: premature ovarian insufficiency,autoimmune,mouse model,proteomics,immune imbalance |
Contact List
| Feiyang Diao | |
|---|---|
| contact affiliation | Nanjing Medical University |
| contact email | diaofeiyang@njmu.edu.cn |
| lab head | |
| Ying Tian | |
| contact affiliation | Nanjing Medical University |
| contact email | tianying@stu.njmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
