PXD077413

PXD077413 is an original dataset announced via ProteomeXchange.

Title	DIA proteomic profiling of dorsal skin from Dendrobium officinale polysaccharide-treated C57BL/6 mice
Description	This project contains DIA-PASEF proteomics data generated from dorsal skin tissues of male C57BL/6 mice in a control group, a DHT-induced androgenetic alopecia (AGA) model group, and a Dendrobium officinale polysaccharide (DOP, 7.5 mg/mL)-treated group. The study was designed to investigate proteomic alterations associated with DHT-induced hair loss and the response to DOP treatment in vivo. After dose screening, 7.5 mg/mL DOP was selected for subsequent mechanistic studies, and skin tissues from the control, model, and DOP groups were subjected to quantitative proteomic analysis. Peptides were analyzed on a nanoElute2–timsTOF Pro2 platform in DIA-PASEF mode, and raw data were processed in Spectronaut using the Pulsar search engine against the reviewed Mus musculus UniProt database.
HostingRepository	iProX
AnnounceDate	2026-04-20
AnnouncementXML	Submission_2026-04-29_01:32:06.186.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuchen Ba
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-20 19:31:24	ID requested
⏵ 1	2026-04-29 01:32:06	announced

Dataset with its publication pending

submitter keyword: Androgenetic alopecia, DHT, Dendrobium officinale polysaccharide, DIA proteomics, mouse skin, C57BL/6, hair follicle, steroid metabolism

Junwen Wang
contact affiliation	the First Hospital of Hunan University of Chinese Medicine
contact email	321396@hnucm.edu.com
lab head
Yuchen Ba
contact affiliation	the First Hospital of Hunan University of Chinese Medicine
contact email	ambyc666@gmail.com
dataset submitter

iProX dataset URI