PXD077377

PXD077377 is an original dataset announced via ProteomeXchange.

Title	Comparative proteomics analysis of wild-type vs Caj1 overexpressing cells
Description	This study presents a comparative label-free quantitative proteomic analysis of Saccharomyces cerevisiae wild-type cells carrying an empty vector (WT + EV), cells overexpressing Caj1 under the TEF1 promoter (TEF1-Caj1) and Caj1 deletion cells carrying an empty vector (del Caj1 + EV) . Caj1 is a cytosolic chaperone, and its overexpression is hypothesized to influence cellular protein homeostasis. Whole-cell lysates were prepared from the indicated strains and subjected to LC–MS/MS analysis. The aim of this study is to identify differentially abundant proteins associated with Caj1 overexpression and to understand its impact on global proteome remodeling. The dataset provides insights into pathways potentially regulated by Caj1 and contributes to understanding chaperone-mediated proteostasis in yeast.
HostingRepository	PRIDE
AnnounceDate	2026-04-28
AnnouncementXML	Submission_2026-04-28_10:05:32.543.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Preeti Sagarika
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: NEWT:4932;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-20 04:48:01	ID requested
⏵ 1	2026-04-28 10:05:33	announced

10.1093/GENETICS/IYAG100;

submitter keyword: Caj1 , Molecular chaperones

Chandan Sahi
contact affiliation	Associate Professor Department of Biological Sciences Indian Institute of Science Education and Research-Bhopal MP, India
contact email	sahi@iiserb.ac.in
lab head
Preeti Sagarika
contact affiliation	JNCASR
contact email	preetisagarika21@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD077377

PRIDE project URI

• PRIDE
  1. PXD077377
     1. Label: PRIDE project
     2. Name: Comparative proteomics analysis of wild-type vs Caj1 overexpressing cells