PXD077368

PXD077368 is an original dataset announced via ProteomeXchange.

Title	Protective effects of Sifangteng on rheumatoid arthritis in rats via regulation of the STAT3-MMPs axis
Description	This study systematically evaluated the therapeutic effects of the traditional Yao medicine Sifangteng formula (SFTF) on rheumatoid arthritis (RA) using a collagen-induced arthritis (CIA) rat model. Multi-omics approaches, including widely targeted metabolomics, TMT-based quantitative proteomics, network pharmacology, WGCNA, and single-cell RNA sequencing analysis, were integrated to identify active components and key molecular targets. The results demonstrated that SFTF attenuates synovial inflammation and joint destruction by regulating the STAT3-MMPs axis. Key bioactive compounds such as quercitrin, hesperidin, and luteolin-7,3'-di-O-glucoside were identified and validated in vitro. This study provides a mechanistic basis for the traditional use of Sifangteng in RA treatment.
HostingRepository	iProX
AnnounceDate	2026-04-20
AnnouncementXML	Submission_2026-04-19_20:16:30.362.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kai Yu
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-19 20:16:01	ID requested
⏵ 1	2026-04-19 20:16:30	announced

Dataset with its publication pending

submitter keyword: rheumatoid arthritis, Sifangteng formula, STAT3-MMPs axis, proteomics, network pharmacology, Yao ethnomedicine

Jianqin Liang
contact affiliation	Guangxi University of Chinese Medicine
contact email	000298@gxtcmu.edu.cn
lab head
Kai Yu
contact affiliation	Guangxi University of Chinese Medicine
contact email	bioneer@foxmail.com
dataset submitter

iProX dataset URI