⮝ Full datasets listing
PXD077112
PXD077112 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | KCNE2 upregulation improves cardiac function by inhibiting Smurf1-mediated SERCA2a degradation in diabetic cardiomyopathy |
| Description | Diabetic cardiomyopathy (DCM) is associated with impaired calcium handling and downregulation of sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase 2a (SERCA2a), though the underlying regulatory mechanisms remain poorly understood. Here, we identify KCNE2, an auxiliary - regulatory subunit of multiple ion channels, as a key regulator of SERCA2a protein stability in the diabetic heart. KCNE2 expression was significantly reduced in high fat diet/streptozotocin-induced diabetic mice and palmitic acid-treated cardiomyocytes. Using LC-MS/MS and co- immunoprecipitation, SERCA2a was identified as a direct binding partner of KCNE2. Knockdown of KCNE2 decreased SERCA2a protein levels without affecting its transcription. Cardiac-specific overexpression of KCNE2 via adenovirus-associated virus 9 delivery restored SERCA2a expression, improved sarcoplasmic reticulum Ca²⁺ cycling, and ameliorated systolic and diastolic dysfunction in diabetic mice. Mechanistically, KCNE2 competitively inhibited the interaction between SERCA2a |
| HostingRepository | iProX |
| AnnounceDate | 2026-04-14 |
| AnnouncementXML | Submission_2026-04-13_20:26:10.099.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ming Song |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-04-13 20:25:54 | ID requested | |
| ⏵ 1 | 2026-04-13 20:26:10 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Ca2+ handling, Diabetic cardiomyopathy, SERCA2a, KCNE2, Smurf1 |
Contact List
| Wenjuan Liu | |
|---|---|
| contact affiliation | Shenzhen University, Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Department of Pathophysiology, School of Medicine |
| contact email | lwj0320@szu.edu.cn |
| lab head | |
| Ming Song | |
| contact affiliation | Shenzhen University Medical School |
| contact email | smingcool@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
