⮝ Full datasets listing
PXD076719
PXD076719 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Genetic code expansion enables site-specific acetylation to reprogram Lunasin toward BRD4 targeting |
| Description | Lunasin is a plant-derived peptide with moderate anticancer activity but has limited potency and undefined molecular targets. To enhance its functional properties, we developed a site-specifically acetylated variant (Lunasin-K29ac) via genetic code expansion. To characterize the molecular interactions underlying its enhanced activity, we performed interactome profiling of a control (pET-22b-CBD), wild-type Lunasin, and Lunasin-K29ac in HT-29 cells using His pull-down MS. |
| HostingRepository | iProX |
| AnnounceDate | 2026-04-07 |
| AnnouncementXML | Submission_2026-04-07_19:48:22.049.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yanan Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | acetylated residue |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-04-07 19:27:10 | ID requested | |
| ⏵ 1 | 2026-04-07 19:48:22 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: human HT-29 cell, LC-MSMS |
Contact List
| Nanxi Wang | |
|---|---|
| contact affiliation | Nanjing University of Chinese Medicine |
| contact email | nanxi.wang@njucm.edu.cn |
| lab head | |
| Yanan Zhang | |
| contact affiliation | Nanjing University of Chinese Medicine |
| contact email | 13039557296@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
