PXD076685

PXD076685 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Impact of Glycosylation on the SARS-CoV-2 Recombinant RBD Vaccine
Description	Comparative analysis was performed at both nucleic acid and protein vaccine levels to provides a reference for the "glycosylation quality control" of SARS-CoV-2 RBD vaccines. For instance, monitoring the glycoform distribution at the N343 site (e.g., ensuring the proportion of the M5 glycoform is ≥30%) can help maintain the structural stability of the vaccine antigen and the consistency of its immunogenicity. Additionally, the findings regarding the characterization of various glycosylation sites can offer a solution to the longstanding challenge of difficult horizontal comparison among different recombinant SARSCoV- 2 RBD protein vaccines.
HostingRepository	PRIDE
AnnounceDate	2026-06-08
AnnouncementXML	Submission_2026-06-07_16:09:37.212.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tie Gao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-07 07:45:53	ID requested
⏵ 1	2026-06-07 16:09:38	announced

Publication List

Wang H, Li X, He P, Yang S, Liu X, Zhu Q, Liu P, Fang X, Wang C, Bi Y, Jiang G, Sun Y, Chen H, Gao T, Luo J, Rong H, Liu X, Wang X, Zhang Y, Hu Z, Investigating the effects and underlying mechanisms of glycosylation sites on the immunogenicity of COVID-19 vaccines. Signal Transduct Target Ther, 11(1):(2026) [pubmed]
10.1038/s41392-026-02751-z;

Wang H, Li X, He P, Yang S, Liu X, Zhu Q, Liu P, Fang X, Wang C, Bi Y, Jiang G, Sun Y, Chen H, Gao T, Luo J, Rong H, Liu X, Wang X, Zhang Y, Hu Z, Investigating the effects and underlying mechanisms of glycosylation sites on the immunogenicity of COVID-19 vaccines. Signal Transduct Target Ther, 11(1):(2026) [pubmed]

10.1038/s41392-026-02751-z;

Keyword List

submitter keyword: S vaccine,LCMS

submitter keyword: S vaccine,LCMS

Contact List

Tie Gao
contact affiliation	1F, Bldg A, No.18 Science Park Road, Life Science Park, Changping District, Beijing 102206, P. R. China
contact email	tie.gao@sciex.com
lab head
Tie Gao
contact affiliation	None
contact email	tie.gao@sciex.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD076685
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD076685

PRIDE project URI

Repository Record List

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