PXD076672

PXD076672 is an original dataset announced via ProteomeXchange.

Title	Identification of copper-binding-induced polymeric protein complexes
Description	Cuproptosis is characterized by copper ion-induced polymerization of lipoylated proteins. Whether other proteins involved in cuprotosis also undergo polymerization in the presence of copper ions remains to be determined. In this study, we utilized three experimental approaches to identify novel copper-induced polymerized proteins associated with cuprotosis. In the first two approaches, melanoma A375 cells were treated with copper ionophores—either elesclomol (ES) or disulfiram (DSF) in combination with copper—prior to cell lysis. In the third approach, cell lysates were directly incubated with copper ions in vitro. The resulting lysates were then subjected to non-reducing gel electrophoresis to detect proteins that undergo copper-induced polymerization. We expect to identify new target proteins of copper ions and new participating and executing proteins of copper death through this method.
HostingRepository	PRIDE
AnnounceDate	2026-04-25
AnnouncementXML	Submission_2026-04-25_03:55:26.589.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kejun Xu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-07 04:20:52	ID requested
⏵ 1	2026-04-25 03:55:27	announced

Dataset with its publication pending

submitter keyword: cuproptosis

polymerization

Copper

Kejun Xu
contact affiliation	State Key Laboratory of Cellular Stress Biology, Xiang’an Hospital, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian Province, P. R. China
contact email	1329490903@qq.com
lab head
Kejun Xu
contact affiliation	Xiamen University
contact email	1329490903@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD076672
     1. Label: PRIDE project
     2. Name: Identification of copper-binding-induced polymeric protein complexes