PXD076592 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of oleuropein effects in steroid-induced osteonecrosis of osteoblasts |
| Description | This study investigates the therapeutic effects of oleuropein on steroid-induced osteonecrosis of the femoral head. MC3T3-E1 osteoblasts treated with methylprednisolone were used to establish an in vitro model. TMT-based quantitative proteomics was performed to identify differentially expressed proteins between the model and OLP-treated groups. Functional annotation including Gene Ontology (GO), KEGG pathway, InterPro (IPR), and subcellular localization analyses was conducted. The results indicate that OLP alleviates osteoblast apoptosis and regulates multiple biological processes, particularly the PI3K-AKT signaling pathway. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-07 |
| AnnouncementXML | Submission_2026-04-07_05:45:28.414.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | LIN lin |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-04-03 15:51:17 | ID requested | |
| ⏵ 1 | 2026-04-07 05:45:28 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: osteonecrosis, PI3K-AKT signaling,proteomics, TMT, osteoblast, apoptosis |
Contact List
| Shishui Lin |
|---|
| contact affiliation | Fujian Medical University |
| contact email | linjianlong5@163.com |
| lab head | |
| LIN lin |
|---|
| contact affiliation | Fujian Medical University |
| contact email | linjianlong5@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD076592 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD076592
- Label: PRIDE project
- Name: Proteomic analysis of oleuropein effects in steroid-induced osteonecrosis of osteoblasts
