PXD076498

PXD076498 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	IWS1 stimulates transcription elongation
Description	Transcription elongation requires the coordination of many factors, but the molecular role of these factors are not fully understood. We used cryo-electron microscopy and in vitro RNA extension assays to show that the histone chaperone IWS1 stimulates transcription using a series of short motifs in its C-terminus that contact separate components of the elongation machinery.
HostingRepository	PRIDE
AnnounceDate	2026-06-08
AnnouncementXML	Submission_2026-06-07_16:09:37.905.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD076498
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Della Syau
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	orbitrap instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-02 03:40:27	ID requested
⏵ 1	2026-06-07 16:09:38	announced

Publication List

10.1093/nar/gkag357;
Syau D, Steinruecke F, Roth S, Schmid E, Adelman K, Walter JC, Farnung L, Structure and function of IWS1 in transcription elongation. Nucleic Acids Res, 54(9):(2026) [pubmed]
10.6019/PXD076498;

10.1093/nar/gkag357;

Syau D, Steinruecke F, Roth S, Schmid E, Adelman K, Walter JC, Farnung L, Structure and function of IWS1 in transcription elongation. Nucleic Acids Res, 54(9):(2026) [pubmed]

10.6019/PXD076498;

Keyword List

submitter keyword: Human, LC-MS/MS

submitter keyword: Human, LC-MS/MS

Contact List

Lucas Farnung
contact affiliation	Department of Cell Biology, Harvard Medical School, Boston, MA, USA
contact email	lucas_farnung@hms.harvard.edu
lab head
Della Syau
contact affiliation	Harvard Medical School
contact email	dsyau@g.harvard.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD076498
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD076498

PRIDE project URI

Repository Record List

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