PXD076495

PXD076495 is an original dataset announced via ProteomeXchange.

Title	Abundance analysis of chromatin-residing proteins during lineage conversion using protein aggregation capture (PAC)
Description	We performed abundance analysis of chromatin-residing proteins in BLaER1 cells during the early stages of B-cell-to-macrophage transdifferentiation. We employed protein aggregation capture (PAC) to analyze chromatin-residing protein abundances at 0, 6 and 24 h after induction of transdifferentiation in the absence and presence of the small-molecule SUMOylation inhibitor ML-792 (SUMOi). Mass spectrometry analyses were executed with high resolution mass spectrometry (LC-MS), using the Evosep One liquid chromatography system coupled to Orbitrap Astral mass spectrometer. Raw Orbitrap Astral data-independent acquisition (DIA) data were processed with DIA-NN. Data ouput from DIA-NN were further processed with ProteoGyver.
HostingRepository	PRIDE
AnnounceDate	2026-05-27
AnnouncementXML	Submission_2026-05-27_07:58:45.277.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Emma Valima
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	L-methionine removal; iodoacetamide derivatized residue
Instrument	quadrupole orbitrap astral instrument

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-02 02:51:52	ID requested
⏵ 1	2026-05-27 07:58:45	announced

10.1007/S00018-026-06255-5;

submitter keyword: mass spectrometry, transdifferentiation,human, chromatin, BLaER1

Jorma J. Palvimo
contact affiliation	Institute of Biomedicine, University of Eastern Finland, Finland
contact email	jorma.palvimo@uef.fi
lab head
Emma Valima
contact affiliation	Institute of Biomedicine, School of Medicine, University of Eastern Finland
contact email	emma.valima@uef.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD076495

PRIDE project URI

• PRIDE
  1. PXD076495
     1. Label: PRIDE project
     2. Name: Abundance analysis of chromatin-residing proteins during lineage conversion using protein aggregation capture (PAC)