PXD076398

PXD076398 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis reveals shared biological pathways linking acrolein to biomolecular changes in the acute phase of rat spinal cord injury
Description	Spinal cord injury (SCI) is a devastating and highly heterogeneous condition that often leads to permanent sensory, motor, and autonomic impairments. Beyond the initial mechanical trauma, a cascade of secondary biochemical events further amplifies tissue damage and functional loss. In this study, we investigate the proteomic consequences of the reactive aldehyde acrolein within the context of secondary injury pathology. Using comparative proteomic analyses, we evaluate biomolecular changes in SCI vs sham injury and acrolein vs saline injection models. We then apply integrated computational approaches to identify shared protein alterations and biological pathways that may mechanistically link acrolein exposure to SCI pathology.
HostingRepository	PRIDE
AnnounceDate	2026-04-02
AnnouncementXML	Submission_2026-04-02_08:35:26.369.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rachel Stingel
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-31 06:59:42	ID requested
⏵ 1	2026-04-02 08:35:26	announced

10.64898/2026.03.11.711153;

submitter keyword: spinal cord injury, proteomics, rat, acrolein

Riyi Shi
contact affiliation	1. Center for Paralysis Research, 2. Department of Basic Medical Sciences, 3. College of Veterinary Medicine, 4. Weldon School of Biomedical Engineering, 5. Purdue University, West Lafayette, IN 47907
contact email	riyi@purdue.edu
lab head
Rachel Stingel
contact affiliation	Purdue University, Center for Paralysis Research
contact email	rstingel@purdue.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD076398

PRIDE project URI

• PRIDE
  1. PXD076398
     1. Label: PRIDE project
     2. Name: Proteomic analysis reveals shared biological pathways linking acrolein to biomolecular changes in the acute phase of rat spinal cord injury