PXD076315

PXD076315 is an original dataset announced via ProteomeXchange.

Title	Repurposing the antiplatelet drug prasugrel for Parkinson’s disease: Evidence of neuroprotective effects and proteomic profiles
Description	Chronic neuroinflammation is a hallmark pathological feature of Parkinson’s disease (PD) that contributes to progressive neuronal death. Current medications are largely palliative, underscoring the need for alternative therapeutic strategies. Drug repurposing offers a cost-effective and time-efficient approach by leveraging established safety profiles. Here, we screened the U.S. Food and Drug Administration–approved drug library using two in vitro PD models: 1-methyl-4-phenylpyridinium (MPP+)-induced primary cortical neurons and lipopolysaccharide (LPS)-induced BV2 microglial cells. Proteomic alterations following prasugrel treatment were profiled using Ingenuity Pathway Analysis. Neuroprotective effects were validated by biochemical assays and further confirmed in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model. We found that prasugrel, an antiplatelet drug used for acute coronary syndrome, exhibited significant neuroprotective and anti-inflammatory effects. It reduced the expression of apoptosis- and inflammation-related proteins, inhibited mitogen-activated protein kinase (MAPK)–mediated neuronal death and suppressed nuclear factor kappa B (NF-κB)-dependent inflammatory signaling. In vivo, prasugrel administration preserved dopaminergic neurons and improved motor performance in MPTP-treated mice. These findings demonstrate that prasugrel mitigates neuronal apoptosis and microglial activation through modulation of MAPK and NF-κB signaling pathways, supporting its development as a repurposed therapeutic candidate for PD.
HostingRepository	PRIDE
AnnounceDate	2026-07-16
AnnouncementXML	Submission_2026-07-15_17:59:19.560.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD076315
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Eunji Cho
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationList	acetylated residue; monohydroxylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-30 05:04:57	ID requested
⏵ 1	2026-07-15 17:59:20	announced

10.6019/PXD076315;

10.1038/S41531-026-01480-Y;

submitter keyword: Prasugrel, Drug repurposing, Proteomics,Parkinson’s disease

Jong Hyuk Yoon
contact affiliation	Neurodegenerative Diseases Research Group, Korea Brain Research Institute
contact email	jhyoon@kbri.re.kr
lab head
Eunji Cho
contact affiliation	Korea Brain Research Institute
contact email	prettybox5@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD076315
     1. Label: PRIDE project
     2. Name: Repurposing the antiplatelet drug prasugrel for Parkinson’s disease: Evidence of neuroprotective effects and proteomic profiles