PXD076262

PXD076262 is an original dataset announced via ProteomeXchange.

Title	Epiproteomic Profiling Identifies Histone H4 Hyperacetylation as a Prognostic Marker in Pleural Mesothelioma
Description	Pleural mesothelioma (PM) is an aggressive tumor that arises from mesothelial cells as a consequence of asbestos exposure. Despite recent therapeutic advances, including immune checkpoint inhibitors and multimodal treatment strategies, the prognosis of PM remains poor, with a median overall survival typically below 18 months. Molecularly, PM is characterized by extensive heterogeneity. Mutations in the epigenetic regulator BRCA1-associated protein 1 (BAP1) are found in approximately one third of cases, underlying the important role of epigenetic dysregulation in PM biology. With the goal of investigating the association between epigenetic alterations in histone PTMs and patient survival and treatment response, we employed state-of-the-art mass spectrometry-based epiproteomics to profile histone PTMs in PM clinical samples. We analyzed a cohort of 96 primary tumors obtained at diagnosis, prior to systemic therapy. Patients were stratified by overall survival using a 15-month cutoff, which approximates the reported median survival for PM. The cohort included 69 patients who did not receive surgery, and 25 patients who underwent surgery following neoadjuvant therapy. For the latter group, paired pre- and post-therapy samples were analyzed to assess whether therapy-induced epigenetic changes correlate with treatment response and survival.
HostingRepository	PRIDE
AnnounceDate	2026-09-04
AnnouncementXML	Submission_2026-09-04_01:47:17.977.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roberta Noberini
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monomethylated residue; acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-27 12:14:12	ID requested
⏵ 1	2026-09-04 01:47:20	announced

Noberini R, Bischinioti I, Zanetti S, Vai A, Sedda G, Mane E, Bardoni C, Robusti G, D'Ercole M, Mancari R, Cavallaro U, Colombo N, Bertolaccini L, Lombardi M, Fusco N, Spaggiari L, Galetta D, Bonaldi T, Epiproteomic profiling identifies histone H4 hyperacetylation as a prognostic marker in pleural mesothelioma. Lung Cancer, 219():109544(2026) [pubmed]

10.1016/j.lungcan.2026.109544;

submitter keyword: histone post-translational modifications, pleural mesothelioma

Tiziana Bonaldi
contact affiliation	European Institute of Oncology, Milan
contact email	tiziana.bonaldi@ieo.it
lab head
Roberta Noberini
contact affiliation	Istituto Europeo di Oncologia
contact email	roberta.noberini@ieo.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD076262

PRIDE project URI

• PRIDE
  1. PXD076262
     1. Label: PRIDE project
     2. Name: Epiproteomic Profiling Identifies Histone H4 Hyperacetylation as a Prognostic Marker in Pleural Mesothelioma