PXD076260

PXD076260 is an original dataset announced via ProteomeXchange.

Title	Ileal proteome reprogramming during superimposed trematode infection
Description	We investigated how repeated intestinal worm infections affect the cells lining the small intestine in mice. Infections with intestinal trematodes can disrupt the normal balance of the gut, leading to tissue damage and altered metabolism. Using a proteomics approach, we measured changes in thousands of proteins in intestinal epithelial cells during a first infection and after a second, repeated infection. We found that the first infection caused stress in the cells, impaired oxygen use, and reduced the activity of pathways that normally help repair tissue. In contrast, the repeated infection triggered a coordinated response that restored many cellular functions. Cells increased protein activity related to fat metabolism, tissue structure, barrier integrity, and antimicrobial defense. We also observed evidence that the immune signaling molecule interleukin-25 plays a central role in coordinating these protective and repair processes. These results suggest that the gut epithelium can adapt to repeated infections by reorganizing its metabolic and structural functions, which may help limit tissue damage and promote partial resistance to parasites. Our study provides a detailed map of the molecular changes that underlie this adaptation, improving our understanding of how the intestinal lining responds to repeated worm infections
HostingRepository	PRIDE
AnnounceDate	2026-07-29
AnnouncementXML	Submission_2026-07-29_03:00:30.838.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luz Valero
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 6600+

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-27 11:30:42	ID requested
⏵ 1	2026-07-29 03:00:31	announced

Dataset with its publication pending

submitter keyword: SWATH,Host adaptation, Echinostoma caproni

Rafael Toledo
contact affiliation	Universitat de València, Facultad de Farmacia y Ciencias de la Alimentación, Área de Parasitología, Departamento de Farmacia y Tecnología Farmacéutica y Parasitología, Valencia, Spain.
contact email	rafael.toledo@uv.es
lab head
Luz Valero
contact affiliation	Universitat de Valencia
contact email	mluz.valero@uv.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD076260

PRIDE project URI

• PRIDE
  1. PXD076260
     1. Label: PRIDE project
     2. Name: Ileal proteome reprogramming during superimposed trematode infection