PXD076158 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dissecting the Functional Divergence of DCAF11 Isoforms in Protein Degradation |
| Description | DCAF11 is a substrate receptor of the Cullin-RING ligase 4 (CRL4) ubiquitin ligase complex and an emerging effector supporting targeted protein degradation. DCAF11 exists as two major isoforms, but their functional differences remain incompletely understood. Here, we show that DCAF11 isoforms 1 and 2 assemble into CRL4 complexes with similar efficiency and exhibit largely overlapping endogenous substrate profiles, including proteins implicated in electrophile detoxification. In contrast, they differ in their compatibility with small-molecule degraders: covalent PROTACs engage both isoforms, whereas a non-covalent molecular glue selectively utilizes isoform 1. These findings reveal isoform-dependent control of protein degradation and highlight opportunities for isoform-selective targeting. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-10 |
| AnnouncementXML | Submission_2026-07-10_09:19:51.992.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xiaoyu Zhang |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | orbitrap instrument |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-25 12:41:11 | ID requested | |
| ⏵ 1 | 2026-07-10 09:19:52 | announced | |
Publication List
Keyword List
| submitter keyword: proteomics,E3 ligase, protein degradation |
Contact List
| Xiaoyu Zhang |
|---|
| contact affiliation | Northwestern University, Department of Chemistry |
| contact email | zhang@northwestern.edu |
| lab head | |
| Xiaoyu Zhang |
|---|
| contact affiliation | Northwestern University |
| contact email | zhang@northwestern.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD076158
- Label: PRIDE project
- Name: Dissecting the Functional Divergence of DCAF11 Isoforms in Protein Degradation
