⮝ Full datasets listing
PXD076052
PXD076052 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Metabolic-engineered probiotic- OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy |
| Description | Lei et al. screen out Lactococcus lactis OMVs (Lac-OMVs) and develop metabolic-engineered NAD+-Lac-OMVs nanovaccine with potent tissue repair therapeutic effect. NAD+-Lac-OMVs sequentially activate dendritic cells by membrane component and reprogram inflammatory macrophages for anti-inflammation and bone repair by interior nicotinamide metabolites. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-23 |
| AnnouncementXML | Submission_2026-03-23_20:49:13.143.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jie Lei |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-23 20:42:53 | ID requested | |
| ⏵ 1 | 2026-03-23 20:49:13 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Bone infection, probiotic outer membrane vesicles, immune regulation, bone repair, anti-infection vaccine |
Contact List
| Cao Yang | |
|---|---|
| contact affiliation | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| contact email | caoyangunion@hust.edu.cn |
| lab head | |
| Jie Lei | |
| contact affiliation | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| contact email | 13823963388@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
