PXD076051

PXD076051 is an original dataset announced via ProteomeXchange.

Title	LncRNA AABR07033564.1-encoded protein AABR40 protects BMECs from OGD/R-induced pyroptosis via BNIP3-mediated mitophagy
Description	This dataset comprises 4D-DIA quantitative proteomics data from primary rat brain microvascular endothelial cells (BMECs) subjected to Oxygen-Glucose Deprivation/Reoxygenation (OGD/R) injury. The aim of the study was to investigate the protective mechanism of the novel protein AABR40, encoded by the lncRNA AABR07033564.1. Comparative proteomic analysis was performed between BMECs overexpressing AABR40 and control vectors following OGD/R insult. Bioinformatic analysis of the proteomic data identified BNIP3 as a key downstream effector, which was subsequently validated to mediate mitophagy. The raw data supports the finding that AABR40 inhibits pyroptosis by activating BNIP3-dependent mitophagy, providing a potential therapeutic target for ischemic brain injury.
HostingRepository	iProX
AnnounceDate	2026-03-23
AnnouncementXML	Submission_2026-03-23_20:41:18.044.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dingyu Rao
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-23 20:40:58	ID requested
⏵ 1	2026-03-23 20:41:18	announced

Dataset with its publication pending

submitter keyword: AABR07033564.1, AABR40, BNIP3, Mitophagy, Pyroptosis

Zhixian Tang
contact affiliation	First affiliated hospital of Gannan Medical University
contact email	tangzhixian@gmu.cn
lab head
Dingyu Rao
contact affiliation	First affiliated hospital of Gannan Medical University
contact email	18329037521@163.com
dataset submitter

iProX dataset URI