PXD075969 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Conformational dynamics of CagM homo-oligomerization by HDX-MS |
| Description | Cag type IV secretion system (CagT4SS) mediates the translocation of a wide spectrum of substrates including oncoprotein CagA to host cells and plays an indispensable role in the pathogenesis of Helicobacter pylori. CagM, one of the central cylinder components responsible for initiating the assembly of CagT4SS, is able to undergo high-order homo-oligomerization. Two CagM mutants, NTD-EK (E29K/K31E/K32E/E33K/E35K/E36K) and DEK (D183E/E184K/E185K), deficient in high-order oligomerization were generated. Here, we performed differential HDX-MS analysis on wild-type, to characterize the interface involved in homo-oligomerization. Our findings reveal the significance of CagM homo-oligomerization on facilitating CagT4SS assembly. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-14 |
| AnnouncementXML | Submission_2026-06-14_09:27:48.892.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chin Yu Mok |
| SpeciesList | scientific name: Helicobacter pylori G27; NCBI TaxID: NEWT:563041; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Synapt MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-21 08:35:33 | ID requested | |
| ⏵ 1 | 2026-06-14 09:27:49 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Type IV secretion system, H. pylori,CagM |
Contact List
| Shannon Wing Ngor Au |
|---|
| contact affiliation | School of Life Sciences, The Chinese University of Hong Kong |
| contact email | shannon-au@cuhk.edu.hk |
| lab head | |
| Chin Yu Mok |
|---|
| contact affiliation | The Chinese University of Hong Kong |
| contact email | yukomokk14@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD075969 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD075969
- Label: PRIDE project
- Name: Conformational dynamics of CagM homo-oligomerization by HDX-MS
