⮝ Full datasets listing
PXD075933
PXD075933 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of extracellular vesicles from inflammatory fibroblasts in colorectal cancer lung metastasis |
| Description | Pulmonary metastasis is a major cause of mortality in colorectal cancer (CRC), and the tumor microenvironment plays a critical role in metastatic progression. In particular, inflammatory fibroblasts have been implicated in shaping the metastatic niche; however, the molecular characteristics of their extracellular vesicles (EVs) remain incompletely understood. In this study, we performed LC-MS/MS-based proteomic analysis of EVs derived from IL-1β–stimulated MRC-5 lung fibroblasts. EVs were isolated from conditioned media of MRC-5 cells with or without IL-1β treatment and subjected to comparative proteomic profiling. This dataset provides a resource for characterizing EV-associated protein alterations in inflammatory fibroblasts and supports further investigation of their potential roles in tumor-related processes in colorectal cancer lung metastasis. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-20 |
| AnnouncementXML | Submission_2026-03-20_02:20:00.890.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Weipeng Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-20 02:19:32 | ID requested | |
| ⏵ 1 | 2026-03-20 02:20:01 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Cancer-associated fibroblasts, Colorectal cancer pulmonary metastasis, Extracellular matrix, Extracellular vesicles |
Contact List
| Weipeng Wang | |
|---|---|
| contact affiliation | College of Pharmaceutical Sciences, Soochow University |
| contact email | wangweipeng@suda.edu.cn |
| lab head | |
| Weipeng Wang | |
| contact affiliation | College of Pharmaceutical Sciences, Soochow University |
| contact email | 2534535983@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
