PXD075920

PXD075920 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics analysis of liver from CCl4 or CDAHFD induced liver fibrosis mice
Description	Liver fibrosis is a crucial and potentially reversible stage in the progression from chronic liver diseases towards liver cirrhosis and hepatocellular carcinoma (HCC). Endoplasmic reticulum (ER) stress is closely related to hepatic stellate cells (HSCs) activation and liver fibrosis. Liver fibrosis is frequently accompanied by a global increase in hepatic protein methylation. This suggests that there may be potential unexplored connections among ER stress, protein methylation, and liver fibrosis. Therefore, this study aims to deeply elucidate whether and how the methylated modification of the ER stress key regulatory protein GRP94, thereby playing a crucial role in mediating the activation of HSCs and liver fibrosis progression.
HostingRepository	iProX
AnnounceDate	2026-03-20
AnnouncementXML	Submission_2026-03-20_01:58:25.633.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xinyi Liu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-20 01:57:20	ID requested
⏵ 1	2026-03-20 01:58:26	announced

Dataset with its publication pending

submitter keyword: liver fibrosis, endoplasmic reticulum stress, methylation

Xiaowei Zhang
contact affiliation	Peking University Health Science Center
contact email	liuxy1127@163.com
lab head
Xinyi Liu
contact affiliation	Peking University Health Science Center
contact email	liuxy1127@163.com
dataset submitter

iProX dataset URI