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PXD075915
PXD075915 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Gut microbiota dysbiosis promotes aortic aneurysm and dissection through FPR1-driven vascular inflammation |
| Description | Aortic aneurysm and dissection (AAD) are life-threatening cardiovascular disorders for which effective preventive strategies remain limited. Although the gut microbiota is recognized as a critical modulator of multiple cardiovascular diseases, its role in AAD remains unclear. Using microbiome sequencing, we identified gut microbiota dysbiosis in AAD patients, characterized by the expansion of Escherichia coli (E. coli). Further evidence indicates that E. coli is a key AAD-promoting strain, exacerbating aortic inflammation. Moreover, through transcriptomic profiling and high-performance liquid chromatography-mass spectrometry analyses, E. coli-derived fMLF was identified as a microbial metabolite that promotes AAD progression via formyl peptide receptor 1 (FPR1). Mechanistically, FPR1 is activated by fMLF in macrophages, enhancing macrophage chemotaxis and the proinflammatory responses through the p38/ERK MAPK signaling pathways. These findings confirm the crucial role of the gut microbiota and its metabolites in the pathogenesis of AAD, and provide insights for developing effective preventive and therapeutic strategies for AAD. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-20 |
| AnnouncementXML | Submission_2026-03-20_01:47:36.317.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tingtao Chen |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF SCP |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-20 01:47:23 | ID requested | |
| ⏵ 1 | 2026-03-20 01:47:36 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Aortic aneurysm and dissection, Gut microbiota, Escherichia coli, Formyl peptide receptor 1, Macrophage, Inflammation |
Contact List
| Tingtao Chen | |
|---|---|
| contact affiliation | Nanchang University |
| contact email | yhfdzs12138@163.com |
| lab head | |
| Tingtao Chen | |
| contact affiliation | Nanchang University |
| contact email | yangxiaoliu123abc@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
