⮝ Full datasets listing
PXD075906
PXD075906 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ubiquitin-driven signaling organization sustains MAPK output under KRAS inhibition in pancreatic ductal adenocarcinoma: Comparative LC-MS/MS analysis of MKRN1-dependent ubiquitination sites on its substrate YES1 |
| Description | This project contains the mass spectrometry data supporting the study of the E3 ubiquitin ligase MKRN1 in regulating therapeutic resistance to KRAS inhibition in pancreatic ductal adenocarcinoma (PDAC). The project includes three independent datasets: 1) AP-MS-based interactome profiling to identify MKRN1-interacting proteins in human PDAC AsPC-1 cells; 2) Comparative LC-MS/MS analysis to map MKRN1-dependent ubiquitination sites on its core substrate YES1; 3) Global quantitative phosphoproteomic profiling of the MKRN1-YES1 axis to identify downstream effectors sustaining MAPK pathway activation in PDAC. All data are associated with the manuscript entitled "Ubiquitin-driven signaling organization sustains MAPK output under KRAS inhibition in pancreatic ductal adenocarcinoma". |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-19 |
| AnnouncementXML | Submission_2026-03-19_20:44:04.766.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chuanzheng Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-19 20:43:36 | ID requested | |
| ⏵ 1 | 2026-03-19 20:44:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: MKRN1, YES1, RAF1, pancreatic ductal adenocarcinoma, KRAS inhibitor resistance, MAPK signaling, AP-MS, ubiquitination site profiling, phosphoproteomics |
Contact List
| Yingke Zhou | |
|---|---|
| contact affiliation | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| contact email | zykwhuh@hust.edu.cn |
| lab head | |
| Chuanzheng Wang | |
| contact affiliation | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| contact email | d202482225@hust.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
