PXD075893

PXD075893 is an original dataset announced via ProteomeXchange.

Title	Basal Proteomics of T-cell lymphoma cell cultures
Description	This dataset contains shotgun LC-MS/MS proteomic data from 30 established T- and NK-cell-derived lymphoma cell cultures. These data were collected to quantify baseline protein abundance across in vitro models of peripheral T- and NK-cell lymphomas. In downstream analyses we identified correlations between variably expressed proteins and drug sensitivities to compounds commonly used in the treatment of hematologic malignancies. These analyses were integrated with results from pooled genome-wide CRISPR screens to identify proteins whose abundance correlates with drug response and whose perturbation alters lymphoma cell sensitivity to these therapies.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-07_04:21:11.214.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Angie Mordant
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	quadrupole orbitrap astral instrument

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-19 17:20:42	ID requested
⏵ 1	2026-09-07 04:21:12	announced

10.1158/1535-7163.mct-25-1263;

Pantazis JC, Pomeroy AE, Palmer AC, Functional genomics and proteomics identify Folate Carrier SLC19A1 as a predictor of pralatrexate sensitivity in diverse T-cell lymphoma models. Mol Cancer Ther, ():(2026) [pubmed]

submitter keyword: T-cells, lymphoma, human, Astral, CRISPR

Adam Palmer
contact affiliation	The University of North Carolina at Chapel Hill, Pharmacology Department
contact email	palmer@unc.edu
lab head
Angie Mordant
contact affiliation	UNC Proteomics Core, Department of Pharmacology, University of North Carolina at Chapel Hill
contact email	angie_mordant@med.unc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD075893

PRIDE project URI

• PRIDE
  1. PXD075893
     1. Label: PRIDE project
     2. Name: Basal Proteomics of T-cell lymphoma cell cultures