⮝ Full datasets listing
PXD075846
PXD075846 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | HflX mediates rifampicin resistance in Brucella by downregulating the expression of RNA polymerase-associated genes |
| Description | To further investigate molecular changes associated with HflX knock during rifampicin exposure, we performed label-free quantitative proteomic analysis. The WT and ΔhflX strains were cultured for three generations in the presence of 1/2 MIC rifampicin (1 μg/mL) and harvested during the logarithmic growth phase, with at least three biological replicates per group. DIA-based proteomic analysis quantified protein abundance and identified differentially expressed proteins (DEPs) (Figure 5A). Bioinformatic analyses were then conducted to evaluate enriched pathways and co-expression networks, aiming to elucidate the regulatory role of HflX in Brucella. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-19 |
| AnnouncementXML | Submission_2026-03-19_00:53:28.870.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hao Geng |
| SpeciesList | scientific name: Brucella abortus 2308; NCBI TaxID: 359391; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-19 00:53:15 | ID requested | |
| ⏵ 1 | 2026-03-19 00:53:29 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Brucella, HflX, Rifampicin resistance, RNA polymerase, Stress response |
Contact List
| Yuefeng Chu | |
|---|---|
| contact affiliation | State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences |
| contact email | chuyuefeng@caas.cn |
| lab head | |
| Hao Geng | |
| contact affiliation | State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences |
| contact email | 82101221325@caas.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
