PXD075824

PXD075824 is an original dataset announced via ProteomeXchange.

Title	Usnic Acid Inhibits Colorectal Cancer Liver Metastasis by Targeting CRYAB Phosphorylation and Inducing Ferroptosis
Description	Here we report that CRYAB phosphorylation serves as a key driver of colorectal cancer liver metastatic progression, and establish usnic acid as an anti-metastatic compound that functions by targeting this post-translational modification. Mechanistically, beyond its canonical pro-apoptotic activity, usnic acid induces ferroptosis through the selective inhibition of CRYAB phosphorylation at serine 59. These findings provide a mechanistic foundation for the development of usnic acid as a potential therapeutic agent for metastatic colorectal cancer, and emphasize the clinical potential of targeting CRYAB phosphorylation and ferroptosis in the management of colorectal cancer liver metastases.
HostingRepository	iProX
AnnounceDate	2026-03-18
AnnouncementXML	Submission_2026-03-18_20:17:28.375.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ziyuan Wan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-18 20:17:08	ID requested
⏵ 1	2026-03-18 20:17:28	announced

Dataset with its publication pending

submitter keyword: Usnic acid, αB-crystallin, colorectal cancer liver metastasis, phosphorylation, hypoxia, ferroptosis, organoids

Jinlai Wei
contact affiliation	the First Affiliated Hospital of Chongqing Medical University
contact email	weilai03109@163.com
lab head
Ziyuan Wan
contact affiliation	Chongqing Medical University
contact email	2891890156@qq.com
dataset submitter

iProX dataset URI