PXD075743

PXD075743 is an original dataset announced via ProteomeXchange.

Title	Usnic acid target CRYAB phosphorylation to induce ferroptosis
Description	This study elucidates the critical role of CRYAB phosphorylation in driving the progression of liver metastasis in colorectal cancer, and validates that usnic acid exerts anti-metastatic activity by modulating this post-translational modification. Mechanistically, in addition to its established pro-apoptotic function, usnic acid triggers ferroptosis via suppressing CRYAB phosphorylation at the S59 site. These results construct a mechanistic basis for usnic acid as a promising therapeutic candidate against metastatic colorectal cancer, underscoring the translational potential of targeting CRYAB phosphorylation and ferroptosis for the clinical intervention of colorectal cancer liver metastases.
HostingRepository	iProX
AnnounceDate	2026-03-17
AnnouncementXML	Submission_2026-03-17_02:14:38.706.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ziyuan Wan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-17 02:14:15	ID requested
⏵ 1	2026-03-17 02:14:39	announced

Dataset with its publication pending

submitter keyword: Usnic acid, αB-crystallin, phosphorylation, ferroptosis

Jinlai Wei
contact affiliation	the First Affiliated Hospital of Chongqing Medical University
contact email	weilai03109@163.com
lab head
Ziyuan Wan
contact affiliation	Chongqing Medical University
contact email	2891890156@qq.com
dataset submitter

iProX dataset URI