PXD075733

PXD075733 is an original dataset announced via ProteomeXchange.

Title	HlncRNA-1 integrates the hepatic circadian clock with lipid metabolism by targeting Hdlbp
Description	The circadian rhythm and lipid metabolism in organisms are tightly coupled, yet the role of lncRNAs in the integration of these two important physiological processes remains unclear. In this study, we identified a liver-specific lncRNA named HlncRNA-1, which regulates lipid metabolism while responding to circadian rhythms. Mice overexpressing HlncRNA-1 exhibited suppressed liver fat accumulation under conditions of both nutrient surplus and deficiency, along with improved insulin sensitivity. In summary, HlncRNA-1 serves as a regulatory conduit that translates circadian clock cues into metabolic outputs, orchestrating circadian control of hepatic lipid metabolism, and activating this lncRNA represents a viable target for precisely intervening in lipid metabolic disorders induced by circadian disruption.
HostingRepository	iProX
AnnounceDate	2026-03-16
AnnouncementXML	Submission_2026-03-17_00:48:06.819.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chen Sun
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-17 00:47:49	ID requested
⏵ 1	2026-03-17 00:48:07	announced

Dataset with its publication pending

submitter keyword: Circadian clock, lipid metabolism, Liver, HlncRNA-1

Chang Liu
contact affiliation	China Pharmaceutical University
contact email	changliu@cpu.edu.cn
lab head
Chen Sun
contact affiliation	Shandong Second Medical University
contact email	sc9417@sdsmu.edu.cn
dataset submitter

iProX dataset URI