PXD075720

PXD075720 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Integrated Proteomic Profiling of Inner Ear and Systemic Fluids Following Noise-Induced Hearing Loss in Rats
Description	This project investigates proteomic changes associated with noise-induced hearing loss (NIHL) using a rat model. Sprague–Dawley rats were exposed to acute broadband noise (110 dB SPL for 1 hour), resulting in an approximately 40 dB auditory threshold shift measured by cochlear nerve compound action potential (CAP). Proteomic profiling was performed on perilymph, cochlear-sourced cerebrospinal fluid (CSF), whole blood, and plasma to identify molecular responses to acoustic trauma. Comparative analysis revealed significant protein alterations across local cochlear fluids and systemic samples, highlighting pathways related to metabolism, immune responses, complement/coagulation, and lipid regulation. The dataset provides a resource for exploring molecular mechanisms of NIHL and identifying potential systemic biomarkers associated with cochlear injury.
HostingRepository	jPOST
AnnounceDate	2026-03-20
AnnouncementXML	Submission_2026-03-19_19:12:57.867.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Motahare Khorrami
SpeciesList	scientific name: Rattus rattus (Black rat); NCBI TaxID: 10117;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-16 22:43:32	ID requested
⏵ 1	2026-03-19 19:12:58	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: Noise-induced hearing loss
Inner ear
Perilymph
cerebrospinal fluid
Proteomics
Data-independent acquisition
Peripheral biomarkers
Acute noise trauma
Rat

submitter keyword: Noise-induced hearing loss

Inner ear

Perilymph

cerebrospinal fluid

Proteomics

Data-independent acquisition

Peripheral biomarkers

Acute noise trauma

Rat

Contact List

Paul A. Haynes
lab head
Motahare Khorrami
contact affiliation	School of Engineering, Macquarie University, Sydney, New South Wales, Australia
dataset submitter

Full Dataset Link List

jPOST dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST004482/

jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST004482/