PXD075677 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Regulation of chromatin dynamics by a calcium-dependent nucleoskeleton |
| Description | This project investigates the mechanisms by which growth factors selectively activate nuclear calcium signaling to regulate gene transcription. While it is established that growth factors trigger an increase in nuclear inositol 1,4,5-trisphosphate (IP3) and subsequent calcium release via intranuclear IP3 receptors (ITPRs), the downstream structural and functional consequences within the nucleoplasm remain under characterization. Our study reveals that this calcium signaling event leads to the transient assembly of an actin nucleoskeleton, which specifically associates with the intranuclear non-muscle myosin 2A (MYH9). |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-15 |
| AnnouncementXML | Submission_2026-05-15_10:17:47.345.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD075677 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | MICHELE ANGELA RODRIGUES |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-16 04:42:53 | ID requested | |
| ⏵ 1 | 2026-05-15 10:17:47 | announced | |
Publication List
Keyword List
Contact List
| Dawidson Gomes |
|---|
| contact affiliation | Department of Biochemistry and Immunology; Universidade Fderald de Minas Gerais (UFMG) |
| contact email | dawidson.gomes@gmail.com |
| lab head | |
| MICHELE ANGELA RODRIGUES |
|---|
| contact affiliation | Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos, 6627, Belo Horizonte – MG, 31270-901, Brazil. |
| contact email | michele.ip3@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD075677 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD075677
- Label: PRIDE project
- Name: Regulation of chromatin dynamics by a calcium-dependent nucleoskeleton
